Progress on the Electrochemical and Electrical Sensing of Pathogenic Bacteria Using Advanced Nanostructures

Sabine SZUNERITS

Institut d’Electronique, de Microélectronique et de Nanotechnologie (IEMN), UMR CNRS 8520, University of Lille, Avenue Poincaré-BP 60069, 59652 Villeneuve d’Ascq, France, e-mail address: sabine.szunerits@univ-lille.fr

Pathogenic bacteria when present in food, water, and other biological samples remain one of the main sources of human diseases as they are infectious to human beings. Over the past years, advanced nanomaterials-based sensing is considered an efficient and unique platform for the rapid, selective, ultrasensitive, qualitative, and quantitative detection of single or multiple pathogenic bacteria. Towards this end, various emerging nanomaterials have been integrated into electrochemical and electrical sensor systems enabling the rapid recognition of pathogenic bacteria presence. In this talk, some of our work on graphene oxide-based sensors toward the identification of harmful bacteria will be discussed. A special focus will be given to innovative surface receptors and their anchoring to the sensor transducer in a controlled manner.

Selected references:

  1. Electrochemical Methodologies for the Detection of Pathogens, M. Amiri, A. Bezaatpour, H. Jafari, R. Boukherroub, S. Szunerits, ACS Sens. 2018, 3, 6, 1069–1086.
  2. Reduced graphene oxide/polyethylenimine based immunosensor for the selective and sensitive electrochemical detection of uropathogenic Escherichia coli, R. Jijie, K. Kahlouchea, A. Barras, N. Yamakawa, J; Bouckaert, T. Gharbib, S. Szunerits, R; boukherroub, Sensors and Actuators B: Chemical, 2018, 260, 255-263.
  3. Entrapment of uropathogenic E. coli cells into ultra-thin sol-gel matrices on gold thin films: A low cost alternative for impedimetric bacteria sensing, H. Jafari, M. Amiri, E. Abdi, S. L. Navid, J. Bouckaert, R. Jijie, R. Boukherroub, S. Szunerits, Biosensors and Bioelectonics 2019, 124-125, 161-166.
  4. Reduced graphene oxide–based field effect transistors for the detection of E7 protein of human papillomavirus in saliva, P. Aspermir, V. Mishyn, J. Bintonger, H. Happy, L. Bagga, P. Subramanian, W. Knoll, R. Boukherroub, S. Szunerits, Analytical and Bioanalytical Chemistry, 2021, 413, 779-787.
  5. The role of the surface ligand on the performance of electrochemical SARS-CoV-2 antigen biosensors, S. Szunerits, Q. Pagneux, A. Swaidan, V. Mishyn, A. Roussel, C. Cambillau, D. Devos, I. Engelmann, E. K. Alidjinou, JH. Happy, R. Boukerroub, S. Szunerits, Analytical and Bioanalytical Chemistry 2021, doi: 10.1007/s00216-020-03137-y.
  6. A Mask-Based Diagnostic Platform for Point-of-Care Screening of Covid-19, J. Daniels, S. Wadekar, K. DeCubellis, G. W. Jackson, A. S. Chiu, Q. Pagneux, H. Saada, I. Engelmann, J. Ogiez, D. Loze-Warot, R. Boukherroub, S. Szunerits, Biosensors and Bioelectronics, 2021, 113486, https://doi.org/10.1016/j.bios.2021.113486